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SECRETORY COMPONENT
Descriptors Found:
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DeCS
Descriptor
English
:
Secretory Component
Descriptor
Spanish
:
Componente Secretorio
Descriptor
Portuguese
:
Componente Secretório
Synonyms
English
:
Secretory Piece
Tree Number:
D12.776.124.486.485.114.619.026.030.500
D12.776.124.486.485.705.875
D12.776.124.790.651.114.619.026.030.500
D12.776.124.790.651.705.875
D12.776.377.715.548.114.619.026.030.500
D12.776.377.715.548.705.875
Definition
English
:
The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile,
colostrum
.)
Secretory component
is derived by proteolytic cleavage of the receptor during
transcytosis
. When
immunoglobulins
IgA and IgM are bound to the receptor, during their
transcytosis
secretory component
becomes covalently attached to them generating SECRETORY
IMMUNOGLOBULIN A
or secretory
IMMUNOGLOBULIN M.
Pharmacological Action:
Immunologic Factors
History Note
English
:
91(76); was see under IMMUNOGLOBULIN FRAGMENTS 1976-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22287
Unique Identifier:
D012635
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS